TY  - JOUR
AU  - Krstić, Milena
AU  - Sovilj, Sofija
AU  - Borozan, Suncica
AU  - Rančić, Milica
AU  - Poljarević, Jelena
AU  - Grguric-Sipka, Sanja R.
PY  - 2016
UR  - https://omorika.sfb.bg.ac.rs/handle/123456789/792
AB  - Phenothiazines are a large group of heterocyclic, aromatic molecules with nitrogen and sulphur between two benzene rings. Their derivatives, N-alkylphenothiazines have substituent on heterocyclic nitrogen atom which gives them different properties. Also, a series of these molecules have substitution on carbon atom at place 2 of phenothiazine benzene ring. Alkylphenothiazines contain aminoalkyl substituent and their alkyl, acyl and sulphonil derivatives, as well as monocyclic and bicyclic heterocycles attached at thiazine nitrogen atom or directly linked to benzene ring. The N-alkylphenothiazines have been known as antipsychotic drugs, but they also possess antibacterial, antifungal, anticancer activity, and ability to react with macromolecules and to coordinate to the metals. Metal complexes with N-alkylphenothiazines are biological active compounds with different antimicrobial activities and cytotoxic effect against tumor cell lines. The large field of application of N-alkylphenothiazines is very attractive in terms of synthesis of new related derivatives, metal complexes, studying their properties and applications. This article presents a review of the literature and a contemporary view at N-alkylphenothiazines - their synthesis and application, as well as their metal complexes which have promising biological effects.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - N -alkylphenothiazines - synthesis, structure and application as ligands in metal complexes
EP  - 471
IS  - 4
SP  - 461
VL  - 70
DO  - 10.2298/HEMIND150331052K
UR  - conv_1234
ER  - 

@article{
author = "Krstić, Milena and Sovilj, Sofija and Borozan, Suncica and Rančić, Milica and Poljarević, Jelena and Grguric-Sipka, Sanja R.",
year = "2016",
abstract = "Phenothiazines are a large group of heterocyclic, aromatic molecules with nitrogen and sulphur between two benzene rings. Their derivatives, N-alkylphenothiazines have substituent on heterocyclic nitrogen atom which gives them different properties. Also, a series of these molecules have substitution on carbon atom at place 2 of phenothiazine benzene ring. Alkylphenothiazines contain aminoalkyl substituent and their alkyl, acyl and sulphonil derivatives, as well as monocyclic and bicyclic heterocycles attached at thiazine nitrogen atom or directly linked to benzene ring. The N-alkylphenothiazines have been known as antipsychotic drugs, but they also possess antibacterial, antifungal, anticancer activity, and ability to react with macromolecules and to coordinate to the metals. Metal complexes with N-alkylphenothiazines are biological active compounds with different antimicrobial activities and cytotoxic effect against tumor cell lines. The large field of application of N-alkylphenothiazines is very attractive in terms of synthesis of new related derivatives, metal complexes, studying their properties and applications. This article presents a review of the literature and a contemporary view at N-alkylphenothiazines - their synthesis and application, as well as their metal complexes which have promising biological effects.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "N -alkylphenothiazines - synthesis, structure and application as ligands in metal complexes",
pages = "471-461",
number = "4",
volume = "70",
doi = "10.2298/HEMIND150331052K",
url = "conv_1234"
}

Krstić, M., Sovilj, S., Borozan, S., Rančić, M., Poljarević, J.,& Grguric-Sipka, S. R.. (2016). N -alkylphenothiazines - synthesis, structure and application as ligands in metal complexes. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 70(4), 461-471.
https://doi.org/10.2298/HEMIND150331052K
conv_1234

Krstić M, Sovilj S, Borozan S, Rančić M, Poljarević J, Grguric-Sipka SR. N -alkylphenothiazines - synthesis, structure and application as ligands in metal complexes. in Hemijska industrija. 2016;70(4):461-471.
doi:10.2298/HEMIND150331052K
conv_1234 .

Krstić, Milena, Sovilj, Sofija, Borozan, Suncica, Rančić, Milica, Poljarević, Jelena, Grguric-Sipka, Sanja R., "N -alkylphenothiazines - synthesis, structure and application as ligands in metal complexes" in Hemijska industrija, 70, no. 4 (2016):461-471,
https://doi.org/10.2298/HEMIND150331052K .,
conv_1234 .