TY  - JOUR
AU  - Božić, Bojan
AU  - Rogan, Jelena
AU  - Poleti, Dejan
AU  - Rančić, Milica
AU  - Trisović, Nemanja
AU  - Božić, Biljana
AU  - Ušćumlić, Gordana
PY  - 2017
UR  - https://omorika.sfb.bg.ac.rs/handle/123456789/880
AB  - A series of six novel 2-(5-arylidene-2,4-dioxotetrahydrothiazole-3-yl) propanoic acids and six corresponding methyl esters were synthesized. All compounds were characterized by melting points, elemental analysis, FT-IR, H-1 and C-13 NMR spectroscopy. Crystal structure of methyl-2-(5-(4-methoxybenzylidene)-2,4-dioxotetrahydrothiazole-3-yl) propionate was confirmed by X-ray analysis. The antiproliferative activity of all synthesized compounds against human colon cancer, breast cancer and myelogenous leukemia cell lines, i.e. HCT-116, MDA-231 and K562, respectively, was evaluated. The results indicate that antiproliferative activity of the synthesized esters is better than the activity of the corresponding acids. All synthesized compounds showed significant antiproliferative effects against HCT116 cells in all tested concentrations (0.01-100 lM). Moreover, in vitro antimicrobial activity against a wide range of tested microorganisms was examined.
T2  - Arabian Journal of Chemistry
T1  - Synthesis, characterization and biological activity of 2-(5-arylidene-2,4-dioxotetrahydrothiazole-3-yl) propanoic acid derivatives
EP  - S2643
SP  - S2637
VL  - 10
DO  - 10.1016/j.arabjc.2013.10.002
UR  - conv_1316
ER  - 

@article{
author = "Božić, Bojan and Rogan, Jelena and Poleti, Dejan and Rančić, Milica and Trisović, Nemanja and Božić, Biljana and Ušćumlić, Gordana",
year = "2017",
abstract = "A series of six novel 2-(5-arylidene-2,4-dioxotetrahydrothiazole-3-yl) propanoic acids and six corresponding methyl esters were synthesized. All compounds were characterized by melting points, elemental analysis, FT-IR, H-1 and C-13 NMR spectroscopy. Crystal structure of methyl-2-(5-(4-methoxybenzylidene)-2,4-dioxotetrahydrothiazole-3-yl) propionate was confirmed by X-ray analysis. The antiproliferative activity of all synthesized compounds against human colon cancer, breast cancer and myelogenous leukemia cell lines, i.e. HCT-116, MDA-231 and K562, respectively, was evaluated. The results indicate that antiproliferative activity of the synthesized esters is better than the activity of the corresponding acids. All synthesized compounds showed significant antiproliferative effects against HCT116 cells in all tested concentrations (0.01-100 lM). Moreover, in vitro antimicrobial activity against a wide range of tested microorganisms was examined.",
journal = "Arabian Journal of Chemistry",
title = "Synthesis, characterization and biological activity of 2-(5-arylidene-2,4-dioxotetrahydrothiazole-3-yl) propanoic acid derivatives",
pages = "S2643-S2637",
volume = "10",
doi = "10.1016/j.arabjc.2013.10.002",
url = "conv_1316"
}

Božić, B., Rogan, J., Poleti, D., Rančić, M., Trisović, N., Božić, B.,& Ušćumlić, G.. (2017). Synthesis, characterization and biological activity of 2-(5-arylidene-2,4-dioxotetrahydrothiazole-3-yl) propanoic acid derivatives. in Arabian Journal of Chemistry, 10, S2637-S2643.
https://doi.org/10.1016/j.arabjc.2013.10.002
conv_1316

Božić B, Rogan J, Poleti D, Rančić M, Trisović N, Božić B, Ušćumlić G. Synthesis, characterization and biological activity of 2-(5-arylidene-2,4-dioxotetrahydrothiazole-3-yl) propanoic acid derivatives. in Arabian Journal of Chemistry. 2017;10:S2637-S2643.
doi:10.1016/j.arabjc.2013.10.002
conv_1316 .

Božić, Bojan, Rogan, Jelena, Poleti, Dejan, Rančić, Milica, Trisović, Nemanja, Božić, Biljana, Ušćumlić, Gordana, "Synthesis, characterization and biological activity of 2-(5-arylidene-2,4-dioxotetrahydrothiazole-3-yl) propanoic acid derivatives" in Arabian Journal of Chemistry, 10 (2017):S2637-S2643,
https://doi.org/10.1016/j.arabjc.2013.10.002 .,
conv_1316 .

TY  - JOUR
AU  - Popov-Pergal, Katarina
AU  - Poleti, Dejan
AU  - Rančić, Milica
AU  - Meden, Antun
AU  - Pergal, Marija V.
PY  - 2010
UR  - https://omorika.sfb.bg.ac.rs/handle/123456789/338
AB  - The derivatives of 5-substituted-2,4-thiazolidinedione have a broad spectrum of biological activities. In this article, new 5-(arylidene)-3-(4-methylbenzoyl)thiayolidine-2,4-diones 3a-k, with arylidene groups such as 4-phenylbenzylidene 3a, 3,4-dimethoxybenzylidene 3b, 2-hydroxybenzylidene 3c, 4-ethoxybenzylidene 3d, 5-methyl-2-furfurylidene 3e, 4-dimethylaminobenzylidene 3f, 1-naphthylidene 3g, 3,4-methylenedioxybenzylidene 3h, 4-benzyloxybenzylidene 3i, benzylidene 3j, and 4-methoxybenzylidene 3k, were synthesized by direct acylation of alkali metal salts of 5-arylidene-2,4-thiazolidinediones with 4-methylbenzoylchloride. Their structures were confirmed by elemental analysis, IR, H-1 NMR and MS spectroscopy. In addition, crystal structure of the compound 3d was determined using single-crystal X-ray diffraction data.
T2  - Journal of Heterocyclic Chemistry
T1  - Synthesis and Structure of New 5-(Arylidene)-3-(4-methylbenzoyl)thiazolidine-2,4-diones
EP  - 228
IS  - 1
SP  - 224
VL  - 47
DO  - 10.1002/jhet.288
UR  - conv_900
ER  - 

@article{
author = "Popov-Pergal, Katarina and Poleti, Dejan and Rančić, Milica and Meden, Antun and Pergal, Marija V.",
year = "2010",
abstract = "The derivatives of 5-substituted-2,4-thiazolidinedione have a broad spectrum of biological activities. In this article, new 5-(arylidene)-3-(4-methylbenzoyl)thiayolidine-2,4-diones 3a-k, with arylidene groups such as 4-phenylbenzylidene 3a, 3,4-dimethoxybenzylidene 3b, 2-hydroxybenzylidene 3c, 4-ethoxybenzylidene 3d, 5-methyl-2-furfurylidene 3e, 4-dimethylaminobenzylidene 3f, 1-naphthylidene 3g, 3,4-methylenedioxybenzylidene 3h, 4-benzyloxybenzylidene 3i, benzylidene 3j, and 4-methoxybenzylidene 3k, were synthesized by direct acylation of alkali metal salts of 5-arylidene-2,4-thiazolidinediones with 4-methylbenzoylchloride. Their structures were confirmed by elemental analysis, IR, H-1 NMR and MS spectroscopy. In addition, crystal structure of the compound 3d was determined using single-crystal X-ray diffraction data.",
journal = "Journal of Heterocyclic Chemistry",
title = "Synthesis and Structure of New 5-(Arylidene)-3-(4-methylbenzoyl)thiazolidine-2,4-diones",
pages = "228-224",
number = "1",
volume = "47",
doi = "10.1002/jhet.288",
url = "conv_900"
}

Popov-Pergal, K., Poleti, D., Rančić, M., Meden, A.,& Pergal, M. V.. (2010). Synthesis and Structure of New 5-(Arylidene)-3-(4-methylbenzoyl)thiazolidine-2,4-diones. in Journal of Heterocyclic Chemistry, 47(1), 224-228.
https://doi.org/10.1002/jhet.288
conv_900

Popov-Pergal K, Poleti D, Rančić M, Meden A, Pergal MV. Synthesis and Structure of New 5-(Arylidene)-3-(4-methylbenzoyl)thiazolidine-2,4-diones. in Journal of Heterocyclic Chemistry. 2010;47(1):224-228.
doi:10.1002/jhet.288
conv_900 .

Popov-Pergal, Katarina, Poleti, Dejan, Rančić, Milica, Meden, Antun, Pergal, Marija V., "Synthesis and Structure of New 5-(Arylidene)-3-(4-methylbenzoyl)thiazolidine-2,4-diones" in Journal of Heterocyclic Chemistry, 47, no. 1 (2010):224-228,
https://doi.org/10.1002/jhet.288 .,
conv_900 .